Team Photograph: Photograph for Associate Director/Director Drug Metabolism and Pharmacokinetics (DMPK)

EQRx has an unprecedented opportunity to fundamentally change the approach to drug development and delivery that is purpose-built and integrates innovative scientific and technological advancements for the benefit of people and society.

Melanie Nallicheri Chief Executive Officer

EQRx believes responsibility can be revolutionary. Want to make a difference while advancing your career? Come join a team that is working towards our bold mission of developing innovative medicines at radically low prices to help people get the medicines they need.

Who We Are

We're a new kind of biotech, one with a bold mission to bring innovative new medicines at dramatically lower costs.

What You’ll Do

The Associate Director or Director of Drug Metabolism and Pharmacokinetics (DMPK) will provide strategic DMPK guidance across functional project teams at EQRx focused on small molecules and biologics in oncology and inflammation/immunology diseases. You will develop DMPK plans (e.g., ADME assays to support discovery and development programs, non-clinical pharmacokinetics, pharmacodynamics and translational principles for selection of development candidate molecules) to support the development and fast registration of EQRx products. You will be responsible for leading the strategy, planning, design, and overseeing the execution of in vitro ADME assays and non-clinical studies to understand the PK and ADME of compounds. You will integrate DMPK data/principles with pharmacology and toxicology profiles and will work cross-functionally on project teams, providing scientific leadership and strategic direction.

You will monitor our work with CROs/external vendors to ensure compliance with agreed protocols, quality standards and timelines. This role will review internal/external data, lead the analysis, interpretation and reporting of ADME, and non-clinical and clinical pharmacokinetic and pharmacodynamic data. You will effectively communicate DMPK knowledge and strategy to project teams, functional leaders, and other key stakeholders. You will co-author regulatory submission documents (CTD, Investigator brochure (IB), EOP2 meetings, BLA). You will report to the VP of Pharmacology.

The Impact You Will Have

This dynamic role will have the opportunity to work across a diverse range of projects with different drug modalities and a breadth of therapeutic areas including oncology and inflammation & immunology disorders. This is not your standard DMPK lead role; this position is highly visible and of significant impact to our patients and company. We are on a critical mission to bring innovative, effective solutions to patients at a fraction of the price. This role will help us drive towards that pinnacle goal of truly putting patients first.

Your Superpowers

  • You have a PhD in life sciences (e.g., pharmaceutical sciences, PK, drug metabolism or a related field) with a minimum of 5 to 7 years of pharmaceutical industry experience.
  • You have solid knowledge of metabolism and ADME (metabolic stability, DDI, plasma/tissue binding, etc), PK, PK/PD, and bioanalytical principles.
  • You have a broad understanding of various DMPK relevant areas such as physiochemical properties, drug metabolizing enzyme and transporter kinetics, mechanistic biotransformation, in silico predictions, and qualitative and quantitative bioanalytical techniques.
  • You have fluency in Model-Informed Drug Development and the ability to integrate in silico, physiochemical, and DMPK data.
  • You have a demonstrated track record and ability to manage the DMPK/pharmacokinetic components of development projects.
  • You have up-to-date knowledge on regulatory guidance pertaining to ADME/DMPK.
  • You are proficient and experienced in using common data analysis software packages (such as Phoenix WinNonlin/NLME, Simcyp, R, SAS, and other tools).
  • You are eager to explore and learn new skills and can work productively in a team environment.
  • You have excellent project management skills.
  • You can participate and work effectively on multiple cross-functional teams

· You understand relationships are key and have strong interpersonal skills.

· You are a strong leader. Teams love working with you and you are someone who takes pride in mentoring and supporting the careers of others.

  • You can thrive in a smaller company environment and love the pace of a true start-up.
  • You’re a team player who is willing to roll-up your sleeves and get the job done.

Are you bold enough?

Your work should matter and allow you the freedom to be 100% you. We spend too much time and effort in our career to not feel excited and proud about what we do and who we do it with. In other words, your career is too important for your next move to be just another job, so let’s work together to change the world and bring affordable medicines to all patients.

We aren’t about a bunch of empty slogans on a wall or words on a coffee cup – you can find that in lots of places. We are a culture of individuals with diverse backgrounds and personalities.

What does EQRx stand for?

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Are you bold enough?

Your work should matter and allow you the freedom to be 100% you. We spend too much time and effort in our career to not feel excited and proud about what we do and who we do it with. In other words, your career is too important for your next move to be just another job, so let’s work together to change the world and bring affordable medicines to all patients.

We aren’t about a bunch of empty slogans on a wall or words on a coffee cup – you can find that in lots of places. We are a culture of individuals with diverse backgrounds and personalities.

The Disruptor

Are you ready to make waves in the industry and change the tides?

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What does EQRx stand for?

  • EQuality Medicines: Equally good or better, innovative medicines
  • EQuitable Medicines: Making innovative medicines affordable
  • EQual Access: Sustainable, frictionless access for people to cutting-edge medicines

We have a bold mission and are looking for equally bold people who want to join us and help make a difference in the world. If you want to grease the wheel we are definitely not for you. Want to build the wheel? We might be just what you are looking for.

EQRx is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, sexual orientation, gender identity, disability status, protected veteran status, or any other characteristic protected by law.

It’s (mutually) beneficial.

You’re curious about what sets us apart from the rest. What do you get from working at EQRx?

So, let’s start big—working at EQRx means having the opportunity to change the world.

By joining a team that’s remaking medicine development from start to finish, you’re going to enjoy the daily rush of throwing caution to the wind and doing things differently by:

  • Working with the smartest game-changers in the industry
  • Cutting down the red tape of “the way things are done”
  • Seeing and feeling the daily impact of your work
  • Growing as a professional and a person
  • Committing to neverending social responsibility

And, yes—we also have a killer list of things that’ll help you shine as part of the team.

But to us, these are just table stakes.

  • 100% Medical, Dental, and Vision coverage
  • Flexible Spending Account
  • Health Reimbursement Account
  • Free snacks and drinks

*As EQRx grows, please note that some of these are subject to change.

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